XRCC1, X-ray repair cross complementing 1, 7515

N. diseases: 410; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 GeneticVariation group BEFREE χ<sup>2</sup> tests showed that XRCC1-194, XRCC1-280 and XPD-312 gene polymorphisms were significantly correlated with the number, location and diameter of the tumors (p<0.05). 28927037 2017
CUI: C0028797
Disease: Occupational Diseases
Occupational Diseases
0.300 Biomarker group CTD_human [Relation of genetic polymorphism of XRCC1 with risks of chronic benzene poisoning]. 15612468 2004
CUI: C1449861
Disease: Micronuclei, Chromosome-Defective
Micronuclei, Chromosome-Defective
0.300 Biomarker phenotype CTD_human [Genetic polymorphism of XRCC1 associated with susceptibility of chromosomal damage in workers exposed by 1,3-butadiene]. 21351625 2010
CUI: C1449862
Disease: Micronuclei, Genotoxicant-Induced
Micronuclei, Genotoxicant-Induced
0.300 Biomarker phenotype CTD_human [Genetic polymorphism of XRCC1 associated with susceptibility of chromosomal damage in workers exposed by 1,3-butadiene]. 21351625 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE Yet, it is necessary to conduct future prospective explorations to gain a better insight into the impact of XRCC1 Arg399Gln polymorphism on glioma risk. 24258108 2014
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group LHGDN XRCC1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers. 18407370 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group LHGDN XRCC1 polymorphism and lung cancer risk. 18999926 2008
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 26
0.500 Biomarker disease GENOMICS_ENGLAND XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. 28002403 2017
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 26
0.500 GeneticVariation disease UNIPROT XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. 28002403 2017
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker disease CTD_human XRCC1 deficiency sensitizes human lung epithelial cells to genotoxicity by crocidolite asbestos and Libby amphibole. 20705543 2010
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 GeneticVariation disease LHGDN XRCC1 codon 399 and ERCC2 codon 751 polymorphism, smoking, and drinking and risk of esophageal squamous cell carcinoma in a North Indian population. 17556064 2007
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.080 GeneticVariation group LHGDN XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk. 17264068 2007
Malignant neoplasm of urinary bladder
0.100 Biomarker disease BEFREE XPD and XRCC1 appear to have no impact on the risk of bladder cancer. 11304692 2001
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 Biomarker disease BEFREE XPD and XRCC1 appear to have no impact on the risk of bladder cancer. 11304692 2001
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.100 Biomarker disease BEFREE XPD and XRCC1 appear to have no impact on the risk of bladder cancer. 11304692 2001
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.100 Biomarker disease BEFREE Xeroderma pigmentosum group D (XPD) and X-ray repair cross-complementing 1 (XRCC1) genes are 2 important susceptibility genes related to lung cancer. 25308691 2016
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker disease BEFREE Xeroderma pigmentosum group D (XPD) and X-ray repair cross-complementing 1 (XRCC1) genes are 2 important susceptibility genes related to lung cancer. 25308691 2016
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker disease BEFREE Xeroderma pigmentosum group D (XPD) and X-ray repair cross-complementing 1 (XRCC1) genes are 2 important susceptibility genes related to lung cancer. 25308691 2016
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker phenotype BEFREE X-ray repair cross-complementing group 1 (XRCC1) plays a key role in DNA repair, genetic instability, and tumorigenesis. 25582318 2015
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 GeneticVariation disease BEFREE X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism (rs25487) has been reported to be related to Pca. 25262700 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation disease BEFREE X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism (rs25487) has been reported to be related to Pca. 25262700 2015
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin
0.040 GeneticVariation disease BEFREE X-ray repair cross-complementing group 1 (XRCC1) and group 3 (XRCC3) polymorphisms are relatively frequent in Caucasian populations and may have implications in skin cancer modulation. 25218703 2014
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation disease BEFREE X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and gastric cancer risk: A HuGE review and meta-analysis. 21216841 2011
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation disease BEFREE X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and gastric cancer risk: A HuGE review and meta-analysis. 21216841 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker group BEFREE X-ray repair cross-complementing group 1 (XRCC1) plays an important role in base excision and single-strand break repair, as a scaffold protein that brings together proteins of the DNA repair complex, and appears to be a candidate for cancer risk. 19465687 2009